Difference between revisions of "Duloxetine-trazodone"
From Psychiatrienet
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| to = trazodone | | to = trazodone | ||
| stop = | | stop = | ||
| − | * ''' | + | * '''Before day 1:''' gradually reduce dosage of duloxetine to a maximum of 60 mg/ day. |
* '''Day 1-7:''' reduce a dosage of 60 mg/day to 30 mg/day. | * '''Day 1-7:''' reduce a dosage of 60 mg/day to 30 mg/day. | ||
* '''Day 8:''' stop administration of duloxetine. | * '''Day 8:''' stop administration of duloxetine. | ||
Revision as of 10:05, 17 November 2009
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Switch medication from duloxetine to trazodone.[1] [2]
Stop duloxetine - Before day 1: gradually reduce dosage of duloxetine to a maximum of 60 mg/ day.
- Day 1-7: reduce a dosage of 60 mg/day to 30 mg/day.
- Day 8: stop administration of duloxetine.
Start trazodone- Day 11: start administration of trazodone in a dosage of 100-150 mg/day.
More information- Duloxetine slows the metabolism of trazodone via CYP2D6.
- Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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