Difference between revisions of "Maprotiline-trazodone"
From Psychiatrienet
| Line 3: | Line 3: | ||
| to = trazodone | | to = trazodone | ||
| stop = | | stop = | ||
| − | * '''Before day | + | * '''Before day 1:''' gradually reduce dosage of maprotiline to a maximum of 75 mg/day. |
* '''Day 1:''' reduce dosage of maprotiline to 50 mg/day. | * '''Day 1:''' reduce dosage of maprotiline to 50 mg/day. | ||
* '''Day 7:''' reduce dosage of maprotiline to 25 mg/day. | * '''Day 7:''' reduce dosage of maprotiline to 25 mg/day. | ||
Revision as of 15:05, 17 November 2009
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Switch medication from maprotiline to trazodone.[1] [2]
Stop maprotiline - Before day 1: gradually reduce dosage of maprotiline to a maximum of 75 mg/day.
- Day 1: reduce dosage of maprotiline to 50 mg/day.
- Day 7: reduce dosage of maprotiline to 25 mg/day.
- Day 14: stop dosage of maprotiline.
Start trazodoneNo wash-out period is needed.
- Day 7: simultaneously start administration of trazodone in a dosage of 100-150 mg/day.
- Day 14: If necessary, increase the dosage of trazodone every 3-4 days with 50 mg to a maximum of 400 mg/day.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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