Difference between revisions of "Paroxetine-trazodone"
From Psychiatrienet
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| to = trazodone | | to = trazodone | ||
| stop = | | stop = | ||
| − | * '''Before day | + | * '''Before day 1:''' gradually reduce dosage of paroxetine to a maximum of 20 mg/ day, when this dosage is > 20 mg/day. |
* '''Day 1:''' reduce dosage of paroxetine to 10 mg/day. | * '''Day 1:''' reduce dosage of paroxetine to 10 mg/day. | ||
* '''Day 8:''' stop administration of paroxetine. | * '''Day 8:''' stop administration of paroxetine. | ||
Revision as of 16:15, 20 November 2009
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Switch medication from paroxetine to trazodone.[1] [2]
Stop paroxetine - Before day 1: gradually reduce dosage of paroxetine to a maximum of 20 mg/ day, when this dosage is > 20 mg/day.
- Day 1: reduce dosage of paroxetine to 10 mg/day.
- Day 8: stop administration of paroxetine.
Start trazodone- Day 9: start trazodone in dosage of 100-150 mg/day.
- If necessary, increase the dosage of trazodone every 3-4 days with 50 mg to a maximum of 400 mg/day.
More information- Paroxetine slows the metabolism of trazodone via CYP2D6, so caution is necessary.
- Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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