Difference between revisions of "Dosulepine-vortioxetine"
From Psychiatrienet
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| − | + | {{Drugswitch | |
| + | | from = agomelatine | ||
| + | | to = vortioxetine | ||
| + | | stop = | stop = | ||
| + | * '''Before day 1:''' gradually reduce dosage of dosulepine to a maximum of 75 mg/day. | ||
| + | * '''Day 1:''' reduce dosage of dosulepine to 50 mg/day. | ||
| + | * '''Day 3:''' reduce dosage of dosulepine to 25 mg/day. | ||
| + | * '''Day 7:''' stop dosulepine | ||
| + | | start = | ||
| + | * A wash-out period is not necessary. | ||
| + | * Start administration of vortioxetine the next day in a dosage of 10 mg/day. | ||
| + | * Occurrence of serotonin syndrome is theoretically possible, so caution is necessary. | ||
| + | }} | ||
Revision as of 13:48, 4 March 2015
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Switch medication from agomelatine to vortioxetine.[1] [2]
Stop agomelatine - Before day 1: gradually reduce dosage of dosulepine to a maximum of 75 mg/day.
- Day 1: reduce dosage of dosulepine to 50 mg/day.
- Day 3: reduce dosage of dosulepine to 25 mg/day.
- Day 7: stop dosulepine
Start vortioxetine- A wash-out period is not necessary.
- Start administration of vortioxetine the next day in a dosage of 10 mg/day.
- Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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