Difference between revisions of "Paroxetine-moclobemide"
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| − | * '''Day 28:''' moclobemide can be started in a normal dosage of 300 mg/day (2 times a day 150 mg). | + | * ''' Day 15-28: ''' a wash-out period of two weeks is necessary |
| + | * '''Day 29:''' moclobemide can be started in a normal dosage of 300 mg/day (2 times a day 150 mg), if necessary increase dose with 25% (up to 50%) of the target dose every 3 days. | ||
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Revision as of 14:36, 21 October 2015
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Switch medication from paroxetine to moclobemide.[1] [2]
Stop paroxetine - Day -7: reduce dosage of paroxetine to 20 mg/day, if this dosage is > 20 mg/day.
- Day 0: dosage of paroxetine is 20 mg/day.
- Day 1: reduce dosage of paroxetine to 10 mg/day.
- Day 8: reduce dosage of paroxetine to 5 mg/day.
- Day 15: stop administration of paroxetine.
Start moclobemide- Day 15-28: a wash-out period of two weeks is necessary
- Day 29: moclobemide can be started in a normal dosage of 300 mg/day (2 times a day 150 mg), if necessary increase dose with 25% (up to 50%) of the target dose every 3 days.
Cave- Occurrence of the serotonin syndrome is possible without wash-out period.
More information- The reduction of the SSRI doses in 7-14 days could cause emotional instability, headache and flu-like symptoms. One could extend this period.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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