Difference between revisions of "Dosulepine-sertraline"
From Psychiatrienet
| Line 12: | Line 12: | ||
| info = | | info = | ||
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary. | * Occurrence of serotonin syndrome is theoretically possible, so caution is necessary. | ||
| − | * Sertraline is a weak inhibitor of CYP2D6, which metabolizes dosulepine. }} | + | * Sertraline is a weak inhibitor of CYP2D6, which metabolizes dosulepine. |
| + | {{review}} | ||
| + | }} | ||
Revision as of 16:52, 28 October 2015
| ||||||||||||||||||||||||||||||||||||
| ||||||||||||||||||||||||||||||||||||
Switch medication from dosulepine to sertraline.[1] [2]
Stop dosulepine - Before day 1: gradually reduce dosage of dosulepine to a maximum of 75 mg/day.
- Day 1: reduce dosage of dosulepine to 50 mg/day.
- Day 3: reduce dosage of dosulepine to 25 mg/day.
- Day 7: stop administration of dosulepine.
Start sertraline- Day 8: start administration of sertraline in a normal dosage of 50 mg/day.
- Day 22: if necessary increase dosage of sertraline to 100 mg/day.
More information- Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
- Sertraline is a weak inhibitor of CYP2D6, which metabolizes dosulepine.
- This switch is currently being reviewed.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
The editors of psychiatrienet.nl take the greatest care to provide up-to-date and accurate information on this site. Nevertheless, mistakes and omissions cannot be entirely excluded. No rights devolve from the information provided. The editors and other providers of information to this site accept no responsibility for the content of this site or for the information provided therein; neither do they accept responsibility for possible damages which may derive from the use of the information on this site or from the linked sites. The editorial board accepts no responsibility for the content of the (linked) sites, for access to them, or for the products and services on these sites, nor for the occurrence of errors, viruses, and/or disruptions in service.
