Difference between revisions of "Imipramine-tranylcypromine"
From Psychiatrienet
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| − | * Because of the half life of desipramine of up to 3 days a washout period of 2 weeks is necessary<ref [ | + | * Because of the half life of desipramine of up to 3 days a washout period of 2 weeks is necessary<ref>DrugBank[http://www.drugbank.ca/drugs/DB01151]</ref> |
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Revision as of 13:45, 4 October 2016
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Switch medication from imipramine to tranylcypromine.[1] [2]
Stop imipramine - Decrease with about 25% of original dose every 3 days
- Because of the half life of desipramine of up to 3 days a washout period of 2 weeks is necessary[3]
Start tranylcypromine- Start tranylcypromine in a low dosage of 20 mg/day for one week.
- After this week the dosage of tranylcypromine can be increased.
Cave- Occurrence of the serotonin syndrome is possible without wash-out period.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
- ↑ DrugBank[1]
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