Difference between revisions of "Escitalopram-agomelatine"
From Psychiatrienet
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Revision as of 11:14, 4 August 2023
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Switch medication from escitalopram to agomelatine.[1] [2] [3]
Stop escitalopram - Before day 1: gradually reduce dosage of escitalopram to a maximum of 10 mg/day, when this dosage is >10 mg/day.
- Day 1: reduce dosage of escitalopram to a maximum of 5 mg/day.
- Day 8: stop administration of escitalopram.
Start agomelatine- Day 9: start administration of agomelatine in a dosage of 25 mg/day.
- Day 16: if necessary, increase dosage of agomelatine to 50 mg/day.
More information- The reduction of the SSRI doses in 7-14 days could cause emotional instability, headache and flu-like symptoms. One could extend this period.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
- ↑ CBG meb, accessed august 2023,SmPC Valdoxan
- ↑ McAllister-Williams RH et al. The use of antidepressants in clinical practice: focus on agomelatine. Hum Psychopharmacol. 2010 Mar 1;25(2):95-102
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