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Switch medication from sertraline to moclobemide.[1] [2]
- Before day 1: gradually reduce dosage of sertraline to a maximum of 50 mg/day, when this dosage is > 50 mg/day.
- Day 1: reduce dosage of sertraline further to 25 mg/day.
- Day 8: stop administration of sertraline.
- Day 8-21: a wash-out period of at least one week is necessary.
- Day 22: start moclobemide the next day in a normal dosage of 300 mg/day.
- Occurrence of serotonin syndrome is reported when a wash-out period (of one week) is not considered.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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