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Tranylcypromine-sertraline

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Tranylcypromine
Type Antidepressant
Group MAO-I
links
Medscape Tranylcypromine
PubChem 5530
PubMed Tranylcypromine
Kompas (Dutch) Tranylcypromine
Wikipedia Tranylcypromine
Sertraline
Type Antidepressant
Group SSRI
links
Medscape Sertraline
PubChem 68617
PubMed Sertraline
Kompas (Dutch) Sertraline
Wikipedia Sertraline

Switch medication from tranylcypromine to sertraline.[1] [2]

Nietinrijdenbord.png Stop tranylcypromine
  • Day 1: decrease the original dose with about 25% every 3 days.
  • Day 9: stop administration of tranylcypromine.
Eenrichtingbord.png Start sertraline
  • Day 28: Start and increase the dose with about 50% of the target dose per week. [3]
Infobord.png More information
  • After the last dose of tranylcypromine it takes about 14 days to restore the activity of the MAO enzymes
  • Occurrence of the serotonin syndrome is possible without this wash-out period.
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
  3. KNMP; Informatorium Medicamentorum 2023; Monografie "tranylcypromine" (Dutch)
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