Citalopram-tranylcypromine
From Psychiatrienet
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Switch medication from citalopram to tranylcypromine.[1] [2]
Stop citalopram - Day 0: gradually reduce dosage of citalopram/escitalopram to a maximum of 20 mg/ day resp. 10 mg/day, when this dosage is respectively > 20 mg/day and > 10 mg/day.
- Day 1: Reduce dosage of citalopram/escitalopram to a maximum of 10 mg/ day resp. 5 mg/day.
- Day 8: stop administration of citalopram/escitalopram.
Start tranylcypromine- Day 8-21: a wash-out period of two weeks is necessary.
- Day 22: Start administration of tranylcypromine in low dosage of 20 mg/day for one week.
- Day 29: after this week the dosage of tranylcypromine can be increased if necessary.
More information- Occurrence of serotonin syndrome is reported when a wash-out period (of one week) is not considered.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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