Tranylcypromine-agomelatine
From Psychiatrienet
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Switch medication from tranylcypromine to agomelatine.[1] [2]
Stop tranylcypromine - Day 1: Decrease the original dose with about 25% every 3 days.
Start agomelatine- Day 15: Start and increase the dose with about 25% of the target dose every 3 days or 50% per week.
More information- Tranylcypromine has to be phased out to avoid withdrawal symptoms.
- Because tranylcypromine is a irrivesible MAO inhibitor, the activity of MAO enzymes will be normal again after two weeks.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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