Fluoxetine-moclobemide
From Psychiatrienet
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Switch medication from fluoxetine to moclobemide.[1] [2]
Stop fluoxetine - Decrease with about 25% of original dose every 3 days
- wait for 5-6 weeks for washout
Start moclobemide- Start at the first day after the washout period of 5-6 weeks with about 25% of target dose.
Cave- Occurrence of serotonin syndrome is reported when a wash-out period (of four weeks) is not considered.
More information- The pharmacologically active metabolite desmethylfluoxetine has a half-life of about 1 week.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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