Switch medication from paroxetine to agomelatine.[1]
[2]
Stop paroxetine
- Day -7: reduce dosage of paroxetine to 20 mg/day, if this dosage is > 20 mg/day.
- Day 0: dosage of paroxetine is 20 mg/day.
- Day 1: reduce dosage of paroxetine to 10 mg/day.
- Day 8: reduce dosage of paroxetine to 5 mg/day.
- Day 15: stop administration of paroxetine.
Start agomelatine
- Day 1: simultaneously start administration of agomelatine in a dosage of 25 mg/day.[3]
- If necessary, increase dosage of agomelatine to 50 mg/day.
More information
- An extra reduction week to paroxetine 2,5 mg/day is sometimes necessary.
- Low doses of paroxetine can be given by a paroxetine-solution.
- The reduction of the SSRI doses in 7-14 days could cause emotional instability, headache and flu-like symptoms. One could extend this period.
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