Switch medication from venlafaxine to vortioxetine.[1]
[2]
Stop venlafaxine
- Day 1-14: gradually reduce dosage of venlafaxine to a maximum of 37,5 mg or 75 mg (slow release)/ day.
- Day 15: stop administration of venlafaxine
Start vortioxetine
- A wash-out period is not necessary.
- Day 15: start administration of vortioxetine in a normal dosage of 10 mg/day.
More information
- Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
- Patients could be directly switched from a SSRI or a SNRI to vortioxetine 10 mg/day. One week after initiation with vortioxetine, the dosage could be increased from 10 mg/day to 20 mg/day.[3]
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