Switch medication from fluoxetine to agomelatine.[1]
[2]
Stop fluoxetine
- Before day 1: reduce dosage of fluoxetine with about 20 mg per week.
- Day 1: when a dosage of 20 mg/day is reached, stop fluoxetine.
Start agomelatine
- Day 2: start agomelatine in a dosage of 25 mg/day.
- Day 9: if necessary, increase dosage of agomelatine to 50 mg/day.
[3]
More information
- The reduction of the SSRI doses in 7-14 days could cause emotional instability, headache and flu-like symptoms. One could extend this period.
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