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Fluoxetine-moclobemide

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Fluoxetine
Type Antidepressant
Group SSRI
links
Medscape Fluoxetine
PubChem 3386
PubMed Fluoxetine
Kompas (Dutch) Fluoxetine
Wikipedia Fluoxetine
Moclobemide
Type Antidepressant
Group MAO-I
links
Medscape Moclobemide
PubChem 4235
PubMed Moclobemide
Kompas (Dutch) Moclobemide
Wikipedia Moclobemide

Switch medication from fluoxetine to moclobemide.[1] [2]

Nietinrijdenbord.png Stop fluoxetine
  • Before day 1: reduce dosage of fluoxetine with about 20 mg per week.
  • Day 1: when a dosage of 20 mg/day is reached, stop fluoxetine.
Eenrichtingbord.png Start moclobemide
  • Day 8-36: a wash-out period of four weeks is necessary.
  • Day 37: start moclobemide in a normal dosage of 300 mg/day, if necessary increase dose with 25% (up to 50%) of the target dose every 3 days.
Letopbord.png Cave
  • Occurrence of serotonin syndrome is reported when a wash-out period (of four weeks) is not considered.
Infobord.png More information
  • The pharmacologically active metabolite desmethylfluoxetine has a half-life of about 1 week.
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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