Mianserine-moclobemide
From Psychiatrienet
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Switch medication from mianserine to moclobemide.[1] [2]
Stop mianserine - Day 0: gradually reduce dosage of mianserine to a maximum of 60 mg/ day.
- Day 1: reduce a dosage of 60 mg/day to 30 mg/day.
- Day 8: stop administration of mianserine.
Start moclobemide- Day 8-14: a wash-out period of one week is necessary.
- Day 15: start administration of moclobemide in a normal dosage of 300 mg/day.
More information- A switch from mianserineto moclobemide is not obvious, given the necessary prolonged wash-out period in this case.
- Occurrence of serotonin syndrome is theoretically possible.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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