Imipramine-citalopram
From Psychiatrienet
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Switch medication from imipramine to citalopram.[1] [2]
Stop imipramine - Before day 0: gradually reduce dosage of imipramine to a maximum of 75 mg/day.
- Day 1: reduce dosage of imipramine to 50 mg/day.
- Day 3: reduce dosage of imipramine to 25 mg/day.
Start citalopram- Day 1: simultaneously start administration of citalopram/escitalopram in a normal dosage of 20 mg/day, resp. 10 mg/day.
- Day 8: stop administration of imipramine and continue administration of citalopram/escitalopram.
More information- Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
- Citalopram/escitalopram are a weak inhibitor of CYP2D6, which metabolizes imipramine.
- Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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