Combining-Lithium-Valproic acid

Lithium Type moodstabilizer Group other links ATC-code N05AN01 Medscape Lithium PubChem 11125 PubMed Lithium Drugs.com lithium Kompas (Dutch) Lithium Wikipedia Lithium more info T1/2 12-48h administration O

Valproic acid Type moodstabilizer Group anticonvulsant links ATC-code N03AG01 PubChem 3121 PubMed acid%22 Valproic acid Drugs.com valproic-acid Kompas (Dutch) Valproic acid Wikipedia Valproic acid more info Cth 50000-100000μg/L Ctox 150000μg/L T1/2 10-15h bioavailability 100% administration O,R

Adding Valproic acid to Lithium.

General information

• Lithium is eliminated by the kidney for about 95%. Changes in the rate of excretion can cause unwanted effects.
• Valproic acid is principally metabolized by CYP2C9, CYP2C19, CYP2A6 and UDP-glucuronosyltransferases. Valproic acid is an inhibitor of the enzymes CYP2C9, epoxide-hydroxylase and UDP-glucuronosyltransferases.
• Lithium is eliminated by the kidney for about 95%. Changes in the rate of excretion can cause unwanted effects.
• Valproic acid is principally metabolized by CYP2C9, CYP2C19, CYP2A6 and UDP-glucuronosyltransferases. Valproic acid is an inhibitor of the enzymes CYP2C9, epoxide-hydroxylase and UDP-glucuronosyltransferases.
• This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination.

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