Mirtazapine-venlafaxine
From Psychiatrienet
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Switch medication from mirtazapine to venlafaxine.[1] [2]
Stop mirtazapine - Before day 1: Gradually reduce dosage of mirtazapine to a maximum of 30 mg/day, when this dosage is > 30 mg/day.
- Day 1: Reduce dosage of mirtazapine to 15 mg/day.
- Day 8: Stop administration of mirtazapine.
Start venlafaxine- Day 8: Start administration of venlafaxine in a normal dosage of 37,5 mg or 75 mg (slow release) /day.. Increase the dose with about 25% of the target dose every 3 days.
Cave- Occurrence of serotonin syndrome is (not very likely) possible, so caution is necessary.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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