Citalopram-duloxetine
From Psychiatrienet
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Switch medication from citalopram to duloxetine.[1] [2]
Stop citalopram - Before day 1: gradually reduce dosage of citalopram to a maximum of 20 mg/day, when this dosage is > 20 mg/day.
- Day 1: reduce dosage of citalopram to a maximum of 10 mg/day.
- Day 8: stop administration of citalopram
Start duloxetine- Day 9: start administration of duloxetine in a dosage of 30 mg/day.
- Day 16: increase dosage of duloxetine 60 mg/day.
More information- Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
- Cross-tapered switch might be possible as well. [3]
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
- ↑ Perahia DG et al. Switching to duloxetine from selective serotonin reuptake inhibitor antidepressants: a multicenter trial comparing 2 switching techniques. J. Clin. Psychiatry 2008 Jan;69(1):95-105
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