Tranylcypromine-agomelatine
From Psychiatrienet
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Switch medication from tranylcypromine to agomelatine.[1] [2]
Stop tranylcypromine - Day 1: decrease the original dose with about 25% every 3 days.
- Day 9: stop administration of tranylcypromine.
Start agomelatine- Day 1: Start with the target dose and increase dose as necessary [3]
More information- After the last dose of tranylcypromine it takes about 14 days to restore the activity of the MAO enzymes[3]
- Tranylcypromine has to be phased out to avoid withdrawal symptoms.[4]
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
- ↑ 3.0 3.1 KNMP; Informatorium Medicamentorum 2023; Monografie "tranylcypromine" (Dutch)
- ↑ Dr. M.J.Blom et al. (2009) Gebruik van klassieke MAO-remmers
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