Fluvoxamine-agomelatine
From Psychiatrienet
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Switch medication from fluvoxamine to agomelatine.[1] [2] [3]
Stop fluvoxamine - Day 1: Decrease dose to 50%
- Day 8: Stop
Start agomelatine- Day 1: simultaneously start administration of agomelatine in a dosage of 25 mg/day.[4]
- Day 11: If necessary, increase dosage of agomelatine to 50 mg/day.
More information- Fluvoxamine inhibits the metabolism of agomelatine via CYP1A2 (90%) and via CYP2C9/2C19 (10%).[4]
- The reduction of the SSRI doses in 7-14 days could cause emotional instability, headache and flu-like symptoms. One could extend this period.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
- ↑ CBG meb, accessed august 2023,SmPC Valdoxan
- ↑ 4.0 4.1 McAllister-Williams RH et al. The use of antidepressants in clinical practice: focus on agomelatine. Hum Psychopharmacol. 2010 Mar 1;25(2):95-102
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