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Switch medication from Olanzapine_LA to Olanzapine[1].[2] [3]
Stop Olanzapine_LA - Day 1: Last depot injection
Start Olanzapine[1]- t= 0 Start dosing 25% of the target dose on the day you normally would have injected the former depot.
- t= 1 x T1/2 of depot approx. 50% of target dose
- t= 2 x T1/2 of depot approx. 75% of target dose
- t= 3 x T1/2 of depot approx. 100% of target dose
- See 'more information' for the T1/2 of this depot
More information- During this switch you could monitor ECG, especially in patients prone to QT-conduction problems.
- There is a possibility of QT interval prolongation.[4]
- the T1/2 of olanzapine depot is approximately 30 days.[5]
- ↑ A. Risselada, Switchen van en naar depotantipsychotica - een update; Psyfar, june 2022 nummer 2
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
- ↑ Stöllberger C, Huber JO, Finsterer J, Antipsychotic drugs and QT prolongation. Int Clin Psychopharmacol. 2005 Sep;20(5):243-51.
- ↑ KNMP Kennisbank, informatorium medicamentorum: Olanzapine
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[[Category:SwitchOlanzapine[1]]]