{{Drugswitch | from = vortioxetine | to = paroxetine | stop =
- Day 1: Decrease with about 25% of the original dose per 3 days.
| start =
- Day 7 and after: At approximately 50-25% of the original vortioxetine dose start paroxetine at 50% of the target dose.
- Day 14: Increase paroxetine to 100% of the target dose
| info =
- Safe target dose paroxetine = 20 mg
- paroxetine is a strong CYP2D6 inhibitor, which metabolize vortioxetine.