Switch medication from agomelatine to fluvoxamine[1][2]
Stop agomelatine
- Day 1: Stop agomelatine.
- Agomelatine can be stopped abruptly for every dosage.[3]
Start fluvoxamine
- Day 1: Start with 50% of the target dose
- Day 8: Increase dose to 100% of the target dose
- Day 9 and after: Gradually increase dose as necessary
More information
- Safe target dose fluvoxamine = 100 mg
- Fluvoxamine stops the metabolism of agomelatine via CYP1A2 and CYP2C9.
- Pharmacokinetic interaction is not important because of low plasma levels.
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Stop agomelatine 
Start fluvoxamine
More information