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Aripiprazole LA-Lurasidone

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Aripiprazole
long acting
Type Antipsychotic
Group Atypical AP
Other use moodstabilizer
links
Medscape Aripiprazole
EMEA abilify
PubChem 60975
PubMed Aripiprazole
Kompas (Dutch) Aripiprazole
Wikipedia Aripiprazole
Lurasidone
Type Antipsychotic
Group Atypical AP
links
Medscape Lurasidone
PubMed Lurasidone
Kompas (Dutch) Lurasidone
Wikipedia Lurasidone

Switch medication from Aripiprazole LA to Lurasidone[1][2][3]

Nietinrijdenbord.png Stop Aripiprazole LA
  • Day 1: Last depot injection
Eenrichtingbord.png Start Lurasidone
  • t= 0 Start dosing 25% of the target dose on the day you normally would have injected the former depot.
  • t= 1 x T1/2 of depot approx. 50% of target dose
  • t= 2 x T1/2 of depot approx. 75% of target dose
  • t= 3 x T1/2 of depot approx. 100% of target dose
  • See 'more information' for the T1/2 of this depot
  • the T1/2 of aripiprazole depot is 46.5 days after administration of 400 mg and approximately 29.9 days after adminstration of 300 mg.[4]
Infobord.png More information
  • More information on switching to lurasidon: see reference. [5]
  1. ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
  3. ↑ A. Risselada, Switchen van en naar depotantipsychotica - een update; Psyfar, june 2022 nummer 2
  4. ↑ KNMP Kennisbank, informatorium medicamentorum: Aripiprazol
  5. ↑ McEvoy JP et al. Effectiveness of lurasidone in patients with schizophrenia or schizoaffective disorder switched from other antipsychotics: a randomized, 6-week, open-label study.J Clin Psychiatry. 2013 Feb;74(2):170-9.
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