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Switch medication from doxepin to agomelatine.[2] [3]
Stop doxepin - Before day 0: gradually reduce dosage of doxepin to a maximum of 100 mg/ day, when this dosage is > 100 mg/day.
- Day 1: reduce dosage of doxepin from 100 mg/day to 50 mg/day.
- Day 8: reduce dosage of doxepin from 50 mg/day to 25 mg/day.
Start agomelatine- Day 1: simultaneously start administration of agomelatine in a dosage of 25 mg/day.
- Day 15: stop administration of doxepin and only continue administration of agomelatine.
- If necessary, increase dosage of agomelatine to 50 mg/day.
- ↑ 1.0 1.1 1.2 1.3 1.4 KNMP; Informatorium Medicamentorum 2023; Monografie "doxepine" (Dutch)
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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