Switch medication from tranylcypromine to hypericum.[1]
[2]
Stop tranylcypromine
- Gradually decrease the dosage of tranylcypromine with 10-20 mg/week.
- When a dosage of 10 mg/day is reached, stop administration.
Start hypericum
- Day 1-14: a wash-out period of two weeks is necessary.
- Day 15: start hypericum after this period in a dosage of 300 mg three times a day (900 mg/day).
More information
- Occurence of the serotonin syndrome is theoretically possible.
- The wash-out period is necessary for the MAO enzymes to restore their function.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
The editors of psychiatrienet.nl take the greatest care to provide up-to-date and accurate information on this site. Nevertheless, mistakes and omissions cannot be entirely excluded. No rights devolve from the information provided. The editors and other providers of information to this site accept no responsibility for the content of this site or for the information provided therein; neither do they accept responsibility for possible damages which may derive from the use of the information on this site or from the linked sites. The editorial board accepts no responsibility for the content of the (linked) sites, for access to them, or for the products and services on these sites, nor for the occurrence of errors, viruses, and/or disruptions in service.
Stop tranylcypromine 
Start hypericum
More information