Clomipramine-trazodone
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Switch medication from clomipramine to trazodone.[1] [2]
Stop clomipramine - Before day 0: gradually reduce dosage of clomipramine to a maximum of 50 mg/ day, when this dosage is > 50 mg/day.
- Day 1: reduce dosage of clomipramine to 25 mg/day.
- Day 8: stop administration of clomipramine.
Start trazodoneNo wash-out period is needed.
- Day 1: simultaneously start administration of trazodone in a dosage of 150 mg/day.
- Day 8: continue only administration of trazodone. If necessary, increase the dosage of trazodone to a maximum of 400 mg/day.
More information- Occurrence of the serotonin syndrome is theoretically possilble, so caution is necessary.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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