Switch medication from tranylcypromine to doxepin.[2]
[3]
Stop tranylcypromine
- Gradually decrease the dosage of tranylcypromine with 10-20 mg/week.
- When a dosage of 10 mg/day is reached, stop administration.
Start doxepin
- Day 1-14: a wash-out period of two weeks is necessary.
- Day 15: start doxepin after this period in a low dosage of 25 mg/day.
More information
- Occurrence of the serotonin syndrome is possible without a wash-out period.
- The wash-out period is necessary for the MAO enzymes to restore their function.
- ↑ 1.0 1.1 1.2 1.3 1.4 KNMP; Informatorium Medicamentorum 2023; Monografie "doxepine" (Dutch)
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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Stop tranylcypromine 
Start doxepin
More information