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Switch medication from bupropion to tranylcypromine.[1] [2]
Stop bupropion - Gradually reduce dosage of bupropion to a maximum of 150 mg/ day.
- When a dosage of 150 mg/day is reached, stop administration.
Start tranylcypromineA wash-out period of two weeks is necessary.
- Day 1-14: wash-out period
- Day 14-21: start tranylcypromine 20 mg/day.
- Day 22: increase dosage of tranylcypromine.
More information- By considering a wash-out period of two weeks (>5 times the elimination half-life of bupropion and its metabolites) it is assured that all bupropion has left the body and no drug interactions occur.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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