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Switch medication from trazodone to amitriptyline.[1] [2]
Stop trazodone - Before day 0: gradually reduce dosage of trazodone to a maximum of 150 mg/day, when this dosage is > 150 mg/day.
- Day 1: reduce dosage of trazodone to 100 mg/day.
- Day 8: stop administration of trazodone.
Start amitriptylineNo wash-out period is needed.
- Day 1: simultaneously start administration of amitriptyline in a dosage of 25 mg/day.
- Day 8: stop administration of trazodone and continue administration of amitriptyline in a dosage of 50 mg/day.
- Start low, go slow.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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