Agomelatine-doxepine
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Switch medication from agomelatine to doxepin.[2] [3]
Stop agomelatine - Agomelatine can be stopped abruptly for every dosage.
Start doxepin- A wash-out period is not necessary.
- Day 1: start administration of doxepin the next day in a dosage of 25 mg/day.
- Day 2: increase dosage of doxepin to 50 mg/day.
- If necessary, increase dosage of doxepin with 25 mg every 2-3 days.
- ↑ 1.0 1.1 1.2 1.3 1.4 KNMP; Informatorium Medicamentorum 2023; Monografie "doxepine" (Dutch)
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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