{{ Drugswitch | from = trazodone | to = sertraline | stop =
- Before day 0: gradually reduce dosage of trazodone to a maximum of 150 mg/day, when this dosage is > 150 mg/day.
- Day 1: reduce dosage of trazodone to 75-100 mg/day.
- Day 8: stop administration of trazodone.
- Day 8-13: wash-out period
| start =
- Day 14: start administration of sertraline in a normal dosage of 50 mg/day.
| info =
- Sertraline dose-dependently inhibits CYP2D6, which metabolizes trazodone.