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Switch medication from mianserine to trazodone.[1] [2]
Stop mianserine - Before day 0: gradually reduce the dosage of mianserine to a maximum of 60 mg/day.
- Day 1: reduce dosage of mianserine to 30 mg/day.
- Day 8: stop administration of mianserine.
Start trazodone- Day 9:Start administration of trazodone in a dosage of 100-150 mg/day
- Day 16:If necessary, increase dosage of trazodone to a maximum of 400 mg/day.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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