Switch medication from hypericum to dosulepine.[1]
[2]
Stop hypericum
- Day 1-14:Gradually decrease the dosage of hypericum.
- Day 15: stop administration of hypericum.
Start dosulepine
- Day 15-30: a wash-out period of at least two weeks is necessary.
- Day 31: start dosulepine 25 mg/day.
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- Occurrence of the serotonin syndrome is possible without wash-out period.
- Hypericum induces enzymes of the CYP P-450 type and P-gp.
- Hypericum probably has MAO-inhibiting properties.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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Stop hypericum 
Start dosulepine
More information