Switch medication from mianserine to venlafaxine.[1]
[2]
Stop mianserine
- Day 0: gradually reduce dosage of mianserine to a maximum of 60 mg/ day.
- Day 1: reduce a dosage of 60 mg/day to 30 mg/day.
Start venlafaxine
- Day 1: simultaneously Start administration of venlafaxine in a normal dosage of 37,5 mg or 75 mg (slow release) /day.
- Day 8: stop administration of mianserine and only continue administration of venlafaxine.
- If necessary, increase the dosage of venlafaxine.
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- Occurrence of serotonin syndrome is (not very likely) possible, so caution is necessary.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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Stop mianserine 
Start venlafaxine
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