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Switch medication from paroxetine to tranylcypromine.[1] [2]
Stop paroxetine Depending on the condition of the patient, there are two scenarios possible:
- Gradually reduce dosage of paroxetine to a maximum of 20 mg/day, and then stop administration abruptly.
- Phase out paroxetine from 20 mg/day, to 10 mg/day for one week, and then stop administration abruptly.
Start tranylcypromine- Both scenarios are followed by a wash-out period of one week.
- Then the administration of tranylcypromine can be started in low dosage of 20 mg/day for one week.
- After this week the dosage of tranylcypromine can be increased if necessary.
Cave- Occurrence of the serotonin syndrome is possible without wash-out period.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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