Switch medication from citalopram to trazodone.[1]
[2]
Stop citalopram
- Gradually reduce dosage of citalopram/escitalopram to a maximum of 20 mg/ day resp. 10 mg/day, when this dosage is respectively > 20 mg/day and > 10 mg/day.
- When a dosage of 20 mg/day, resp. 10 mg/day, is reached, stop administration.
Start trazodone
- No wash-out period is needed.
- Start trazodone the next day in normal dosage of 150 mg/day.
- If necessary, increase the dosage of trazodone to a maximum of 400 mg/day.
More information
-
- Occurrence of the serotonin syndrome is possible without wash-out period.
- Citalopram/escitalopram slows the metabolism of trazodone via CYP2D6, so caution is necessary.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
The editors of psychiatrienet.nl take the greatest care to provide up-to-date and accurate information on this site. Nevertheless, mistakes and omissions cannot be entirely excluded. No rights devolve from the information provided. The editors and other providers of information to this site accept no responsibility for the content of this site or for the information provided therein; neither do they accept responsibility for possible damages which may derive from the use of the information on this site or from the linked sites. The editorial board accepts no responsibility for the content of the (linked) sites, for access to them, or for the products and services on these sites, nor for the occurrence of errors, viruses, and/or disruptions in service.
Stop citalopram 
Start trazodone
More information