Switch medication from moclobemide to trazodone.[1]
[2]
Stop moclobemide
- Before day 0: gradually reduce dosage of moclobemide to a maximum of 300 mg/day, when this dosage is > 300 mg/day.
- Day 1: reduce dosage of moclobemide to 150 mg/day.
- Day 8: stop administration of moclobemide.
Start trazodone
- Day 8-9: a wash-out period of two days is necessary.
- Day 10: start administration of trazodone in a dosage of 100 mg/day.
- Day 17: if necessary, increase the dosage of trazodone to a maximum of 400 mg/day.
More information
- Occurrence of the serotonin syndrome is theoretically possilble, so caution is necessary.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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Stop moclobemide 
Start trazodone
More information