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Switch medication from fluvoxamine to trazodone.[1] [2]
Stop fluvoxamine - Before day 0: gradually reduce dosage of fluvoxamine to a maximum of 50 mg/ day, when this dosage is > 50 mg/day.
- Day 1: reduce dosage of fluvoxamine to 25 mg/day.
- Day 8: stop administration of fluvoxamine.
Start trazodone- Day 8: start trazodone in dosage of 100-150 mg/day.
- Day 15: If necessary, increase the dosage of trazodone every 3-4 days with 50 mg to a maximum of 400 mg/day.
Start trazodone the next day in normal dosage of 150 mg/day.
- If necessary, increase the dosage of trazodone graduallyto a maximum of 400 mg/day.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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