Switch medication from sertraline to paroxetine.[1]
[2]
Stop sertraline
- Gradually reduce dosage of sertraline to a maximum of 50 mg/ day, when this dosage is > 50 mg/day.
- When a dosage of 50 mg/day is reached, stop administration.
Start paroxetine
- No wash-out period is needed.
- Start paroxetine the next day in normal dosage of 20 mg/day.
More information
- Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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Stop sertraline 
Start paroxetine
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