Switch medication from mirtazapine to sertraline.[1]
[2]
Stop mirtazapine
- Before Day 0: gradually reduce dosage of mirtazapine to a maximum of 30 mg/ day.
- Day 1: reduce a dosage of 30 mg/day to 15 mg/day.
- Day 7: stop mirtazapine.
Start sertraline
- Day 8: start sertraline in a normal dosage of 50 mg/day.
- Day 14: if necessary increase dosage of sertraline.
More information
- Sertraline slows dose-dependently the metabolism of mirtazapine through CYP2D6.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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Stop mirtazapine 
Start sertraline
More information