Switch medication from duloxetine to clomipramine.[1]
[2]
Stop duloxetine
- Day 0: gradually reduce dosage of duloxetine to a maximum of 60 mg/ day, when this dosage is > 60 mg/day.
- Day 1: reduce dosage of duloxetine to a maximum of 30 mg/day.
- Day 8: stop administration of duloxetine.
Start clomipramine
- Day 11: start administration of clomipramine in a low dosage 25 mg/day.
- Day 15: increase dosage of clomipramine.
More information
- Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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Stop duloxetine 
Start clomipramine
More information