Switch medication from amitriptyline to bupropion.[1]
[2]
Stop amitriptyline
- Before day 0: gradually reduce dosage of amitriptyline to a maximum of 100 mg/ day, when this dosage is > 100 mg/day.
- Day 1-3: reduce dosage of amitriptyline to 50 mg/day.
- Day 4-7: reduce dosage of amitriptyline to 25 mg/day.
- Day 12: stop administration of amitriptyline.
Start bupropion
- Day 14: start administration of bupropion in a dosage of 150 mg/day.
More information
- Bupropion is a strong inhibitor of CYP2D6, which metabolizes amitriptyline.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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Stop amitriptyline 
Start bupropion
More information