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Aripiprazole-Sertindole

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Ariprazole
Type Antipsychotic
Group Atypical AP
Other use moodstabilizer
links
EMEA abilify
PubChem 60975
PubMed Ariprazole
Kompas (Dutch) Ariprazole
Wikipedia Ariprazole
Sertindole
Type Antipsychotic
Group Atypical AP
links
PubChem 60149
PubMed Sertindole
Kompas (Dutch) Sertindole
Wikipedia Sertindole

Switch medication from Aripiprazole to Sertindole.[1] [2]

Nietinrijdenbord.png Stop Aripiprazole
  • Day 1-28: Continue drug at usual dose
  • Day 29: Stop drug
Eenrichtingbord.png Start Sertindole
  • Day 1-4: approx. 25% of target dose
  • Day 5-8: approx. 50% of target dose
  • Day 9-12: approx. 75% of target dose
  • Day 13: target dose
  • Day 28: Reevaluate dose, if necessary adjust dose
Infobord.png More information
  • During this switch ECG monitoring is required because of possible QT-interval prolongation[3][4]
    StopAbruptly28StartGradually2.jpg
Nietinrijdenbord.png — Aripiprazole
Eenrichtingbord.png — Sertindole


  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
  3. SPC Sertindole (Dutch)
  4. SPC Sertindole
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