Clozapine-Haloperidol

more info
DDD	8mg ^[1]
dose	0.25-15mg ^[2]
C_th	5μg/L ^[3]
C_tox	20μg/L ^[4]
EQ-dosage	1^[4] haloperidol
T_1/2	17.5h ^[3]^[2]
bioavailability	60-70% ^[2]
administration	O,IM,IV

Switch medication from Clozapine to Haloperidol.^[5] ^[6]

Stop Clozapine

Day 1: Decrease daily dose with 25 mg every 2 days

Start Haloperidol

Day 1-4: approx. 25% of target dose
Day 5-8: approx. 50% of target dose
Day 9-12: approx. 75% of target dose
Day 13: target dose

More information

During this switch you could monitor ECG, especially in patients prone to QT-conduction problems.
There is a possibility of QT interval prolongation.^[7]

↑ WHO Collaborating Centre for Drug Statistics Methodology ATC=N05AD01
↑ ^2.0 ^2.1 ^2.2 KNMP; Informatorium Medicamentorum 2023; Monografie "haloperidol" (Dutch)
↑ ^3.0 ^3.1 The Lundbeck Institute; Psychotropics; Terminal Plasma Half-lives
↑ ^4.0 ^4.1 Farmacotherapeutisch Kompas; Inleidende Tekst Antipsychotica (dutch)
↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
↑ Stöllberger C, Huber JO, Finsterer J, Antipsychotic drugs and QT prolongation. Int Clin Psychopharmacol. 2005 Sep;20(5):243-51.

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[1] WHO Collaborating Centre for Drug Statistics Methodology ATC=N05AD01

[informatorium-2] 2.0 ^2.1 ^2.2 KNMP; Informatorium Medicamentorum 2023; Monografie "haloperidol" (Dutch)

[pts-3] 3.0 ^3.1 The Lundbeck Institute; Psychotropics; Terminal Plasma Half-lives

[ftkin-4] 4.0 ^4.1 Farmacotherapeutisch Kompas; Inleidende Tekst Antipsychotica (dutch)

[5] Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules

[6] Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.

[7] Stöllberger C, Huber JO, Finsterer J, Antipsychotic drugs and QT prolongation. Int Clin Psychopharmacol. 2005 Sep;20(5):243-51.

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Psychiatrienet β

Clozapine-Haloperidol

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