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Switch medication from Clozapine to Chlorpromazine.[1] [2]
Stop Clozapine - Day 1: Decrease daily dose with 25 mg every 2 days
Start Chlorpromazine- Week 1: approx. 25% of target dose
- Week 2: approx. 50% of target dose
- Week 3: approx. 75% of target dose
- Week 4: target dose
More information- During this switch you could monitor ECG, especially in patients prone to QT-conduction problems.
- There is a possibility of QT interval prolongation.[3]
- During this switch monitoring of the haematological parameters is necessary.
— Clozapine — Chlorpromazine
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
- ↑ Stöllberger C, Huber JO, Finsterer J, Antipsychotic drugs and QT prolongation. Int Clin Psychopharmacol. 2005 Sep;20(5):243-51.
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